123 Tight Glucose Regimen in Critically Ill Infants

Tight blood glucose control is renoprotective in critically ill patients.

Two large, prospective, randomized, controlled trials have shown a beneficial effect of intensive insulin therapy (IIT) on the kidney function of critically ill patients. The data from these trials were combined for performance of a more detailed analysis of the renoprotective effect of IIT. After exclusion of 41 patients with preadmission ESRD, the study sample comprised 2707 critically ill pa...

Tight glycemic control in critically ill adults.

Tight glucose control in critically ill patients: should glucose meters be used?

Measurement of blood glucose concentrations using portable, hand-held meters is used widely in patients with diabetes. Clinical settings include self-monitoring of blood glucose by patients, in doctors’ offices, in chronic care facilities, and in hospitals. More recently, evidence has emerged suggesting that tight glycemic control of nondiabetic patients in hospital intensive care units (ICUs) ...

Tight Glycemic Control in Critically Ill Children.

BACKGROUND In multicenter studies, tight glycemic control targeting a normal blood glucose level has not been shown to improve outcomes in critically ill adults or children after cardiac surgery. Studies involving critically ill children who have not undergone cardiac surgery are lacking. METHODS In a 35-center trial, we randomly assigned critically ill children with confirmed hyperglycemia (...

Hyperammonaemia in critically ill septic infants

Three infants with subphrenic abscess, pyonephrosis, and obstructive ureterocoele respectively had grossly increased concentrations of plasma ammonia. This was considered to be a result of infections with urea splitting organisms. All died in spite of intensive care support, including specific measures to reduce plasma ammonia. (Arch Dis Child 2001;84:512–513)